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The efficacy of imitrex nasal spray in the acute treatment of migraine headaches was demonstrated in 8, randomized, double-blind, placebo-controlled studies, of which 5 used the recommended dosing regimen and used the marketed formulation.

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John s wort, meperidine demerol , lithium lithobid, eskalith , triptans for example, sumatriptan imitrex, alsuma , and tramadol ultram use of selective serotonin inhibitors may increase the risk of gastrointestinal bleeding in patients...

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